干燥综合征唇腺组织中Bcl-2和Bax蛋白表达的意义

Expressions of Bcl-2 and Bax in salivary gland of patients with Sjogren′s syndrome

目的探讨Bcl-2/Bax在干燥综合征(SS)唇腺组织中的表达和意义。方法采用免疫组织化学的方法,对18例SS患者及8例正常对照唇腺组织中Bcl-2、Bax蛋白的表达进行检测。结果Bax在SS患者唇腺组织细胞和导管上皮内大量表达,与对照组相比差异有显著性(P<0.05),而Bcl-2的阳性表达明显低于对照组。结论SS患者唇腺组织中Bax的增加及Bcl-2的减少都与促进细胞凋亡有关,可能是导致腺体破坏进而功能丧失的原因之—。

Objective To observe the expression of Bcl-2/Bax in salivary gland of patients with Sjogren′s syndrome (SS). Method The tissues from 18 patients with SS and 8 normal controls were assessed by immunohistochemical technique. Result Bax was significantly expressed in acinar and ductal epithelial cells in SS, but the expression of Bcl-2 was decreased. Conclusion In SS salivary glands, the expression of Bax may promote apoptosis, but the expression of Bcl-2 may inhibit apoptosis.