胰岛素样生长因子-1受体在淋巴结阴性、淋巴结阳性乳腺癌组织和正常乳腺组织中的表达

The expression of insulin-like growth factor-1 receptor on LN ( - )breast cancer,LN( + )breast cancer and normal breast tissue

目的:探讨胰岛素样生长因子-1受体(in sulin-like growth factor-1 receptor,IGF-1R)在淋巴结阴性、淋巴结阳性的乳腺癌组织和正常乳腺组织中的分布和表达。方法:采用免疫组织化学方法,对淋巴结阳性、淋巴结阴性的乳腺癌组织和正常的乳腺组织中IGF-1R的表达情况进行检测分析。结果:淋巴结阴性的乳腺癌组织中IGF-1R的阳性表达率为94.12％(16／17),淋巴结阳性的乳腺癌组织中IGF-1R的阳性表达率为91.30％(21／23),正常组织中IGF-1R的阳性表达率为58.33％(7／12)。淋巴结阴性的乳腺癌组织中有12例呈强阳性表达(强表达率70.59％)。淋巴结阳性的乳腺癌组织中有8例呈强表达(强表达率34.78％)。淋巴结阳性和淋巴结阴性的乳腺癌组织中IGF-1R的阳性表达率均明显较正常乳腺组织高(P<0.05),淋巴结阴性的乳腺癌组织中IGF-1R的强表达率比淋巴结阳性的乳腺癌组织高(P<0.05)。结论:由此推断,IGF-1R在乳腺癌发生发展过程中发挥着重要作用。IGF-1R有可能成为临床乳腺癌诊断和判断预后的一个重要指标。

Objective : To evaluate the distributing and expression of insulin-like growth,factor-1 receptor of LN( - ) breast cancer, UN( + ) breast cancer and normal breast tissue. Methods: The IGF-1R expression on LN( - )breast cancer, LN( + ) breast cancer and normal breast tissue was tested by im-munohistochemistry. Results: The positive rateon LN( - ) breast cancer was 94.12%o(16/17), on LN/( + )breast cancer was 91.30%o(21/23) ,and on normal breast tissue was 58.33% (7/12) . The number of strongstein was 12 on LN( - )breast cancer(strong stein rayte70.59%) , and 8 on LN( + ) breast cancer(strong stein rate 34.78% ) . The positive rate on the LN( - )breast cancer and LN( + ) breast cancer was higer than it on the normal breast tissue( P < 0.05) , the overexpression rate on the LN ( - ) breast cancer was higher than it on LN ( + ) breast cancer( P < 0.05 ) . Conclusion : These data suggested that IGF-1R play an important role in pathogenesis and development of breast cancer. IGF-1R maybe a adjuvant indexfor diagnosing to breast cancer and estimating prognosis.