血浆内皮素和血管紧张素Ⅱ含量变化与高血压病程度的关系

The relationship between uariation of angiotensin I and endothelin and severity ltypertension

目的:探讨血浆内皮素和血管紧张素Ⅱ与高血压病变程度的关系。方法:选择65例原发性高血压(EH)病人设为病变组,85例健康人设为对照组,均于清晨空腹采血测定其血浆内皮素(ET)和血管紧张素Ⅱ(AⅡ)含量。结果:EH患者血浆ET及AⅡ含量均明显高于正常人且两者存在明显正相关关系(P<0.01)。Ⅰ期EH患者血浆ET含量较正常人轻度升高(P>0.05),而AⅡ含量显著升高(P<0.01),Ⅱ、Ⅲ期高血压患者血浆ET和AⅡ含量均显著高于Ⅰ期患者(P<0.01)。结论:ET和AⅡ为高血压密切相关,且与高血压程度有一定关系。

Objective : To evaluate the relationship between endothelin-angiotensin Ⅱ levels and severity of essential Hypertension. Methods : 65 patients with diagnosed essential hypertension and 85 normal persons were divided into sick group and control group. All blood samples were colleted to measure the levels of ET and A Ⅱ . Results: The levels of ET and A D of the patients with EH were significantly higher than that of wormal persons and there was a position between ( P < 0.01) . The plasma level of ET of the patients with 1st stage hypertension was slightly higher than that of normal human ( P > 0.05) ,while the level of A Ⅱ was markedly higher ( P < 0.01 ) .The plasma level of ET and A Ⅱ of the patients with 2nd,3rd stage hypertension was siginificantly higher than that of those with 1st stage hypertension (P < 0.01) . Conclusion : There is a close relationship between EH and A Ⅱ and the severity of essential hypertension.