急性毒鼠强重度中毒与多器官功能障碍综合征初探

On multi-organ dysfunction syndrome from severe acute toxication of Tetramine

目的 探讨急性毒鼠强重度中毒与多器官功能障碍综合征 (MODS)的关系。方法 收集 2 0例重度急性毒鼠强中毒患者的临床资料 ,与同期收治的 18例重度氟乙酰胺中毒患者的临床资料进行比较。结果 毒鼠强组与氟乙酰胺组都有癫痫样发作 ,但毒鼠强组具有较高的癫痫持续状态、后遗脑电图 (EEG)异常发生率 ,心肌酶 (CK Mb)升高 ,血小板数下降等多器官损害表现 ,易发生MODS。结论 毒鼠强较氟乙酰胺中毒病情凶险。

Objective To investigate the clinical characteristics of acute toxic patients from large dosage of Tetramine and the relationship between multi-organ dysfunction syndrome. Methods Clinical data of 20 cases from acute tetramine poisoning was gathered to compare with that of 18 cases from severe fluoroacetamide poisoning in the corresponding period. Results Epileptic-like seizure was found in both groups,but the former(tetramine poisoning group) exhibited a lasting status epilepticus,multiple organ dysfunction syndrome(MODS),abnormal electroencephalogram(EEG),increased creatine kinase(CK-Mb),thrombopenia and damaging multi-organs. Conclusion Tetramine toxication can result in severe condition than Fluoroacetamide,for which can induce MODS when complicated by disease such as anoxic,infection,accidentally inhale and gastroenteric mucosa injury.