血管内皮细胞生长因子水平对肺癌预后的影响

The prognostic value of vascular endothelial growth factor in lung cancer

目的 探讨血管内皮细胞生长因子 (VEGF)水平对肺癌预后的作用。方法 采用ELISA方法对肺癌组 (112例 )、对照组 (4 8例 )、健康组 (31例 )的血清、尿液及恶性胸腔积液 (4 6例 )和结核性胸腔积液 (31例 )中VEGF水平进行检测 ,并对其进行分析。结果 肺癌组血清VEGF含量 [(5 0 6 .2 2± 36 5 .0 6 ) μg/ml]明显高于对照组 [(2 37.16± 16 8.0 9) μg/ml]和健康组 [(131.32± 99.76 ) μg/ml](P <0 .0 0 1) ;血清VEGF的水平与病变侵袭程度、淋巴结转移、远处转移、生存时间密切相关 ;而与性别、组织学类型无关 ;恶性胸腔积液中VEGF含量 [(937.2 3±4 0 0 .92 ) μg/ml]明显高于结核性胸腔积液组 [(2 5 7.4 1± 36 1.4 7) μg/ml](P <0 .0 0 1) ;肺癌组尿液VEGF水平也明显增高 [(16 7.4 0± 186 .89) μg/ml]。 结论 血清VEGF检测可作为临床预测肺癌患者预后的重要指标之一。

Objective To evaluate the prognostic value of vascular endothelial growth factor (VEGF) in patients with lung cancer.Methods VEGF level was measured by sandwich ELISA in 112 cases with lung cancer.48 diseased control group and 31 healthy individuals.as well as 46 cases of malignant effusion and 31 cases of tuberculosis pleural effusion.Results The serum、urine and pleural effusion VEGF levels in patients with lung cancer were (506.22±365.06)μg/ml、(167.40±186.89)μg/ml and(937.23±400.92)μg/ml respectively,which were significantly higher than those of diseased control groups and healthy groups.The serum and urine VEGF level in patients with lung cancer were significantly higher in advanced stage of the disease (P<0.01) than those in early stage.As to the degree of invasion (T factor),the serum and urine VEGF levels of T4 invasive lesions were significantly higher than those with T1~T2 invasion(P<0.01).The same was also true in patients with lung cancer having lymph node metastasisN3 than that without lymph node metastasis N0 (P<0.01).The pleural effusion VEGF level in lung cancer patients was significantly higher than those with tuberculosis effusion, and also higher than those in serum.(P<0.01).Conclusions VEGF in serum is one of prognostic factor for lung cancer and may be proposed for use in the clinic.