醒脑静对脑梗死急性期患者智能障碍的改善作用

Effect of xingnao jing in improving the cognitive dysfunction of patients with cerebral infarction at acute phase

目的:评价脑梗死急性期患者应用醒脑静注射液治疗后智能与日常生活能力的改善情况。方法:选择上海第二医科大学附属新华医院58例急性期脑梗死住院患者,符合脑卒中的诊断标准,病变部位均选择基底核单发腔隙病灶,排除甲状腺疾病和假性抑郁痴呆。58例患者随机分为醒脑静治疗组和丹参对照组,治疗并观察2周,在治疗前和治疗后2周进行简易精神状况检查表(MMSE)及其10个智能亚项、日常生活功能表(ADL)的测定,同时进行不良反应观察。结果:两组治疗2周后MMSE和ADL量表评分以及地点定向、语言复述、阅读理解能力治疗后两组均有明显好转(P<0.01,0.05);而醒脑静治疗组治疗后MMSE总分为(18.57±2.87)分,明显优于对照组(17.81±2.61)分,差异有显著性意义(P<0.05)。时间定向、短程记忆、物体命名能力治疗组有显著改善(P<0.05),而对照组改善差异无显著性意义(P>0.05)。两组均未见明显副作用。结论:醒脑静和丹参对脑梗死急性期智能障碍和生活能力均有改善作用,醒脑静对智能障碍改善方面明显优于丹参。

AIM:To evaluate the improvements of intelligence and activities of daily living(ADL) in patients with acute cerebral infarction(ACI) after treatment of xingnao jing injection. METHODS:Fifty eight inpatients with ACI were selected from the Affiliated Xinhua Hospital of Shanghai Second Medical University.All the patients were in accordance with the diagnostic criteria of the Fourth National Academic Meeting for Cerebrovascular Disease,and their lesion sites were all at basal nuclei solitary lacuna focal;while those with disease of thyroid gland and pseudodementia and depression were exclued.All he patients were randomly divided into xingnao jing treatment group(treatment group) and danshen group(control group),they were treated and followed up for 2 weeks and evaluated by mini mental state examination(MMSE) and the ten subitems of intelligence and ADL scale, and the side effects of drug were observed at the same time. RESULTS:The MMSE and ADL scores and the abilities of location orientation, language repetition,and reading comprehension were improved significantly in both groups two weeks after treatment(P< 0.01, 0.05).After treatment,the total score of MMSE in the treatment group(18.57±2.87) was significantly superior to that in the control group(17.81±2.61)(P< 0.05).The abilities of time orientation, short time memory and object naming were significantly ameliorated in the treatment group(P< 0.05), while there was no obvious improvement in the control group(P >0.05). No side effects were observed in both groups. CONCLUSION:Both xingnao jing and danshen have the effect of improving the cognitive dysfunction and ADL of patients with ACI,and xingnao jing can improve their cognitive dysfunction better than danshen.