鼠痘的病理诊断及分析

The Pathological Diagnosis and Analysis of Mousepox

鼠痘是由鼠痘病毒引的实验小鼠的一种烈性传染病，分为急性和慢性两型，但大部分为隐性感染。鼠痘的病理组织学特点是，出现皮疹，肝脏、脾脏、肠道、淋巴结、肾脏等出现程度不同的灶性坏死，在这些损伤部位的上皮细胞和内皮细胞出现境界清楚、周围有晕、成群存在、嗜酸性胞浆内包涵体．利用鼠痘抗体，通过免疫酶组织化学染色，可以对组织内鼠痘病毒进行定位诊断。电镜下，在肝脏等组织内可观察到鼠痘病毒颗粒。

ousepox is a serious infections disease of laboratory mice. It has been described as occurring in two forms , a rapidly fatal form, with few or nocutaneous lesions, and a chronic form, characterized by ulceration of the skin and particularly of the feet, tail and snout. Pathohistologically, the li-ver and the spleen contain numerous tissue necrotic areas different in degreeEosinophilic cytoplasmic inclusion bodies in groups which have clear bordercan be demonstrated in rash in the epidermal cells of the skin, eyelidsand the liver.By means of ABC dyeing and utilizing the antibody of poxvirusof mice, the position of the poxvirus of mice in the tissue can be diagnosed.Both in the rapidly fatal form and in the rapid period of the chronicform of the mousepox, the antibody of poxvirus of mice can be positive.