创伤对小鼠抗感染能力及腹腔巨噬细胞吞噬作用的影响

EFFECT OF TRAUMA ON ANTI-INFECTION AND PHAGOCYTOSIS OF PERITONEAL MACROPHAGES IN MICE

以截肢小鼠作为手术创伤动物模型,观察了创伤对小鼠抗感染能力及腹腔巨噬细胞吞噬作用的影响.实验表明,创伤后机体对细菌感染的敏感性明显高于对照组(p<0.05),腹腔巨噬细胞的吞噬能力受到抑制(P<0.01).提示创伤所致的巨噬细胞吞噬功能抑制可能与创伤后感染有关.

This study of effects of trauma on anti-infection and phagocytosis of peritoneal macrophages was carried out in mice. The results, showed that after the mice were inoculated with staphylococcal aureus the rate of se-' pticemia and the mortality in trauma group was higher than in control group within 7 days (P<0.05). The phagocytosis of the peritoneal macrophages from mice was significantly inhibited after the surgical trauma treatments (P<0.01). It was considered that the inhibition of macrophages function may be related with the infection following the trauma.