摘要
目的 :观察三七总皂苷 (PNS)对鹅膏蕈氨酸 (IBA)所致痴呆大鼠模型的学习记忆行为及海马内乙酰胆碱 (ACh)含量的影响。方法 :将IBA注入大鼠Meynert基底核 (NBM )中建立痴呆模型 ,以生理盐水为阴性对照物 ,通过Morris水迷宫观察PNS对其学习记忆能力的改变 ,并用分光光度法测定海马内ACh的含量。结果 :PNS能够改善痴呆模型大鼠的学习记忆能力 ,提高海马内ACh的含量。结论 :PNS对痴呆大鼠的学习记忆能力降低有较好的治疗作用 ,提高海马内ACh含量可能为其作用机理之一。
OBJECTIVE:To observe the effects of Panax notoginseng saponins(PNS)on learning and memory ability of ibotenic acid(IBA)-induced Alzheimer’s disease model of mouse and content of acetylcholine(ACh)in hippocamˉpus.METHODS:To develop the model by injecting into basalis magnocellularis with IBA.The models were treated with PNS and NS.Learning and memory ability were measured by Morris water maze and content of ACh in hippocampus by specˉtrophotometry.RESULTS:PNS can increase learning and memory ability and the content of ACh in hippocampus of model mouse.CONCLUSION:The reduction of learning and memory ability of mouse could be treated with PNS,and the increase of the content of ACh in hippocampus may be one of the mechanism of the effects.
出处
《中国药房》
CAS
CSCD
2004年第10期598-600,共3页
China Pharmacy
关键词
三七总皂苷
痴呆
学习记忆
乙酰胆碱
Panax notoginseng saponins
Alzheimer’s disease
learning and memory
acetylcholine
