用水生态毒理学方法评价13种硝基苯类化合物的急性毒性

Assessment of acute toxicity about 13 kinds of nitrobenzol compound by aquatic ecological toxicological assay

目的 评价常见的 13种硝基苯类化合物的急性毒性。方法 采用毒理学方法中的静水试验分别考查了 13种硝基苯类化合物对大型蚤 (Daphniamagna ,HB)的 2 4h和 4 8h半数致死浓度 (LC50 )。结果 硝基苯类化合物因其取代基的不同或其取代基位置的不同而对大型蚤表现出不同的毒性 ,且对二硝基苯的毒性最强 ,其 2 4hLC50 和 4 8hLC50 分别为 0 .98± 0 .0 3mg·L-1、0 .2 7± 0 .0 2mg·L-1。结论 对二硝基苯属极毒类物质 。

Objective To assess acute toxicity about 13 kinds of nitro benzol compounds.Methods The paper researched 13 kinds of nitriobenzol compounds to daphnia magna (HB), for a medina lethal concentration in 24 h and 48 h,that is,24 h LC_(50) and 48 h LC_(50),by aquatic toxicological assay in motionless water.Results That the different toxicity of the nitrobenzol compounds to HB,because of different substituent and different position of substituent.And the p-dinitrobezene had the greatest toxicity, the 24 h LC_(50) and 48 h LC_(50) were 0.98±0.03 mg·L^(-1) and 0.27±0.02 mg·L^(-1) respectively.Conclusion The p-dinitrobezene is extreme poisonous substance, so that enough attention should bepaid to the effect of such compound to aquatic environment and ecology.