4种结缔组织病患者血管内皮细胞生长因子检测的分析被引量：1

The clinical signifcance of determining serum vascular endothelial growth factor in four diseases orginated comnective tissue

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摘要目的检测4种结缔组织病患者血清中血管内皮细胞生长因子(VEGF)水平,并探讨其意义。方法115例患者中,类风湿关节炎(RA)40例,系统性红斑狼疮(SLE)30例,多发性肌炎/皮肌炎(PM/DM)25例,系统性硬化症(SSc)20例,正常对照30例,采用酶联免疫吸附试验(ELISA)方法检测了血清中的VEGF(ng/L)的含量。结果血清VEGF水平(单位ng/L)分别为RA558.58±348.45,SLE244.63±87.44,PM/DM355.12±258.56,SSc362.72±177.52,类风湿关节炎、系统性红斑狼疮、多发性肌炎/皮肌炎、系统性硬化症患者血清VEGF水平均明显高于正常对照(P<0.01,P<0.05)。结论血清VEGF水平的测定对结缔组织病病情监测可能具有非常重要意义。 Objective To know the clinical significance of serum vascular endothelial growth factor (VEGF) level in connective tissue diseases. Methods The concentration of VEGF were determined in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM ) or systemic sclerosis (SSc) and in normal control by ELISA. Results The serum concentrations of VEGF of RA, PM/DM or SSc were significantly higher than that of normal controls respectively (P<0.01). The serum VEGF level of SLE was significantly higher than that of normal controls (P<0.05). Conclusion The measurement of serum concentration of VEGF is a noninvasive, useful method for monitoring the disease activities of connective tissue diseases.

作者龙武彬吴晓丹朱静刘建周彬

机构地区四川省人民医院风湿科

出处《江西医学检验》 2004年第5期401-402,共2页 Jiangxi Journal of Medical Laboratory Sciences

关键词患者血清结缔组织病 VEGF 系统性硬化症正常皮肌炎水平结论重要意义 Vascular endothelial growth factor Rheumatoid arthritis Systemic lupus erythematosus Polymyositis/Dermatomyositis Systemic sclerosis

分类号 R593 [医药卫生—内科学] R735 [医药卫生—肿瘤]

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