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KIR2DL5基因研究进展

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摘要 杀伤细胞免疫球蛋白样受体(killer-cell immunoglobulin-like receptors,KIPs)是由一组位于19q13.4的紧密成簇的基因编码的免疫球蛋白超家族受体,蛋白结构具有多样性。KIR2DL5由于其独特的基因转录表达特征、单倍体分布、群体分布和表达的多样性,以及D0-D2免疫球蛋白样胞外段结构域和较长的胞内段结构特征而有别于其他KIR,在KIR研究中尤为重要。本文拟对这一基因的研究进展作一综述。
作者 张磊 范丽安
机构地区 上海第二医科大学上海市免疫学研究所
出处 《国外医学（遗传学分册）》 2004年第5期279-281,313,共4页 Foreign Medical Sciences(Section of Genetics )
基金 上海市科委重点项目(No.02DJ14054) 国家自然科学基金资助项目(No.30371350)
关键词 KIR DL 胞外段 免疫球蛋白样受体 基因研究 杀伤细胞 基因转录 结构域 表达特征 免疫球蛋白超家族
分类号 R392 [医药卫生—免疫学] R394 [医药卫生—医学遗传学]
  • 相关文献

参考文献12

  • 1张磊,Katharine C.Hsu,LIU Xiao-rong,杨珏琴,姚芳娟,许玲娣,Bo Dupont,范丽安.人类KIR基因PCR-SSP分型及家系研究[J].上海免疫学杂志,2003,23(2):99-103. 被引量：27
  • 2Hsu KC, Liu XR, Selvakumar A, et al. Killer Ig-like receptor (KIR)haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes,each with multiple subsets. J Immunol, 2002,169: 5118-5129.
  • 3Gómez-Lozano N, Clair M, Parham P, et al. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. Immunogenetics, 2002,54: 314-319.
  • 4Annalise MM, Jerzy KK, Campbell W, et al. Leukocyte Ig-like receptor complex(LRC) in mice and men. Trends Immunol,2002, 23:81-88.
  • 5Norman PJ, Stephens HA, Verity DH, et al. Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups. Immunogenetics, 2001,52: 195-205.
  • 6Marsh SGE, Parham P, Dupont B, et al. Killer-cell immunoglobulin-like receptor (KIR) nomenclature report,2002. European Journal of Immunogenetics,2003,30: 229-234.
  • 7Vilches C, Parham P. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. The Journal of Immunology, 2000, 165: 6416-6421.
  • 8Shilling HG, Yonung N, Guethlein LA, et al. Genetic control of human NK cell receptoire. J Immunol, 2002,169: 239-347.
  • 9Dohring C, Samaridis J, Colonna M. Alternatively spliced formsof human killer inhibitory receptors. Immunogenetics, 1996,44: 227-230.
  • 10Vilches C, Rajalingam R, Uhrberg M, et al. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol,2000,164: 5797-5804.

二级参考文献17

  • 1Diefenbach A, Raulet DH. Strategies for target cell recognition by natural killer cells. Immunol Rev, 2001,181: 170-184.
  • 2Ljunggren HG, Karre K. In search of the missing self: MHC molecules and NK cell recognltlon. Immunol Today, 1990, 11:237-244.
  • 3Cohen GB, Gandhi RT, Davis DM, et al. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.Immunity,1999,10, 661-671.
  • 4Kaerre K. Immunology A perfect mismatch. Science, 2002,295:2029-2031.
  • 5Gómez-Lozano N, Vilches C. Genotyplng of human killer-cell immunoglobulin-like receptor gene by polymerase chain reaction with sequence-specific primers., an update. Tissue Antigens, 2002,59: 184-193.
  • 6Uhrberg M, Valiante NM, Shum BP, et al. Human diversity in killer cell inhibitory receptor genes. Immunity, 1997,7: 753-763.
  • 7Norman PJ,Stephens HA,Verity DH, et al. Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups. Immunogenetics, 2001,52: 195-205.
  • 8Hsu KC, Liu XR, Selvakumar A, et al. Killer Ig-llke receptor(KIR) haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes,each with multiple subsets. J Immunol, 2002,169 : 5118-5129.
  • 9Yawata M, Yawata N, McQueen KL, et al. Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics, 2002,54:543-550.
  • 10Ljunggren HG, Karre K. In search of the missing self:MHC molecules and NK recognition [J]. Immunol Today, 1990,11:237.

共引文献49

国外医学（遗传学分册）
2004年 第5期

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