摘要
本文采用乳化交联法制备了可附载放射性核素的磁靶向药物载体 磁性壳聚糖复合微球。考察了壳聚糖浓度、Fe3O4 壳聚糖质量比及搅拌速度等因素对磁性壳聚糖微球粒径、粒径分布以及形貌等对复合过程的影响 ,确定了制备高磁响应性的磁性壳聚糖的最佳条件 ,并借助不同手段对磁性壳聚糖的粒径、粒径分布、形貌及磁性能进行了初步表征。
In this paper, magnetic chitosan microspheres which can load radionuclides were prepared by the suspension cross-linking technique. The results demonstrated that the concentration of chitosan solution, Fe 3O 4/chitosan ratio and stirring rate of the suspension medium were the most effective parameters for the size/size distribution, morphology and magnetism of magnetic chitosan microspheres. Furtherly, the best preparation circuit is optimized. Finally, the size, size distribution, morphology and magnetism were studied by different instruments.
出处
《材料科学与工程学报》
CAS
CSCD
北大核心
2004年第5期660-662,共3页
Journal of Materials Science and Engineering
基金
国家自然科学基金资助项目 (50 30 60 0 8)
江苏省自然科学基金资助项目(BK2 0 0 342 1 )
关键词
放射性核素
载体
磁性壳聚糖微球
制备
radionuclide
carriers
magnetic chitosan microspheres
preparation
