补肾祛痰化瘀法治疗中老年男性冠心病心绞痛的临床研究

Clinical Study on Treating Coronary Angina Pectoris in Middle-aged and Elderly Men with Method of Tonifying Kidney, Removing Phlegm and Resolving Blood Stasis

目的 :观察补肾祛痰化瘀法治疗中老年男性冠心病心绞痛的疗效 ,研究其机理 ,探讨补肾祛痰化瘀法对下丘脑 -垂体 -性腺轴激素分泌功能紊乱的调节作用。方法 :选择符合肾虚痰瘀证标准的中老年男性冠心病心绞痛患者 180例 ,随机分为治疗组和对照组 ,分别口服心舒胶囊和血府逐瘀胶囊 ,疗程 30d ,观察心绞痛症状、肾虚证候、血脂、血流变及激素FSH、LH、E2 、T、E2 /T各组自身治疗前后的差异及治疗后两组间的差异。结果 :与治疗前比较 ,除对照组激素各项指标改善无显著性差异外 ,两组其他各项指标改善差异有显著性 ;治疗后各项指标的改善 ,治疗组优于对照组 ,有显著性差异。结论 :符合肾虚痰瘀证的中老年男性冠心病心绞痛患者都有下丘脑 -垂体 -性腺轴激素分泌功能紊乱现象 ,用补肾祛痰化瘀法治疗 ,能调节其激素分泌功能 ,改善各项观察指标 ,是肾虚痰瘀证中老年男性冠心病心绞痛的有效治法。

Objective: To observe the therapeutic effects of the method of tonifying kidney, removing phlegm and resolving blood stasis on coronary angina pectoris in middle-aged and elderly men, to research its mechanism and to discuss its regulating action on hormone secretion disorders of hypothalamus-pituitary-gonad axis. Method: 180 middle aged and old men with coronary angina pectoris that met the entry standard of kidney deficiency were chosen. They were randomly divided into treating group and control group and were dealt with Xinshu Capsule and Xuefuzhuyu Capsule respectively, and the drugs were administrated orally. The Period of treatment is 30 days. The differences between the indexes obtained before and after treatment of each group and those between the two groups after treatment were observed in terms of manifestations of angina, syndrome of kidney deficiency, blood fat, hemorheology, as well as hormones like FSH, LH, E2, T and E2/T. Result: Compare to indexes before treatment, except for the improvement of hormone indexes in the control group, there were obvious differences between other index improvements in the two groups. After treatment, the index improvements in treating group were superior to the ones in the control group, and the differences were significant. Conclusion: All patients meet the standard of kidney deficiency have hormone secretion disorders of hypothalamus-pituitary-gonad axis. To treat it with method of tonifying kidney, removing phlegm and resolving blood stasis can regulate its hormone secretion and improve the indexes observed above. And it is an effective therapy for coronary angina pectoris in the middle-aged and elderly men.