摘要
目的 了解石菖蒲主要成分β-细辛醚的药代动力学特征。方法 以HPLC法测定ig大鼠血清和各器官(脑、心、肺、肾、肝)中β-细辛醚的浓度,把器官当作相对独立的系统,用DAS软件进行药代动力学分析。结果 β-细辛醚在大鼠体内的药代动力学过程属一级一室动力学模型,血清半衰期为54 min;达峰时间12min;达峰浓度3.19 mg·L-1。各器官与血清有相似的动力学过程。结论 β-细辛醚在体内吸收、分布、代谢较迅速,极易透过血脑屏障,大脑是重要的分布器官。
Aim To study the pharmacokinetics of β-asarone in rats. Methods The concentration of β-asarone in serum and organs were measured by HPLC after ig administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system. Results The pharmacokinetics of β-asarone can be described as first order process of one-compartment model. In the serum, T1/2, Tpeak and Cmax were 54 min, 12 min and 3. 19 mg ·L-1 , respectively. The procedure in the organs was similar to that in serum. Conclusion The absorption, distribution and elimination of β-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of β-asarone.
出处
《药学学报》
CAS
CSCD
北大核心
2004年第10期836-838,共3页
Acta Pharmaceutica Sinica