慢传输型便秘大鼠结肠肌电生理变化及其意义

The change in myo-electric activity of colon in rats with slow transit constipation

目的 通过研究慢传输型便秘大鼠结肠肌电变化 ,探讨结肠传输功能障碍的机制。方法 建立大鼠慢传输型便秘模型 ,并测定其结肠的肌电生理活动改变。结果 与正常对照大鼠比较 ,慢传输型便秘大鼠结肠肌电慢波出现双向改变 ,一部分大鼠结肠肌电慢波频率减慢 (5 5 5± 1 2 0次 /min ,P <0 0 1) ,幅值增大(0 4 3± 0 0 5mV ,P <0 0 1) ,另一部分大鼠则出现结肠慢波频率增快 (30 85± 3 86次/min ,P <0 0 1) ,幅值强弱不等(0 2 1± 0 0 3mV ,P <0 0 1)。结论 慢传输型便秘大鼠结肠肌电慢波节律及振幅的异常改变可能是导致结肠传输减慢的重要因素。

s Objective To study the pathogenesis of slow transit constipation by investigating the changes in colonic myoelectric activity in rats with slow transit constipation. Methods A rat model of slow transit constipation was replicated and the colonic myoelectric activity was recorded. Results Compared with normal rats, the frequency of myoelectric activity in a part of rats in the model group was seen to be decreased (5.55±1.20/min,P<0.01), while in others increased (30.85±3.86/min,P<0.01). Conclusion The changes in rhythm and amplitude of colonic electric activity were found in rats with slow transit constipation, suggesting that abnormality of colonic electric activity might be responsible for slow transit of colon.