糖尿病大鼠胃窦肌间神经丛氮能神经的变化及其意义

Change in nitriergic nerves in myenteric plexus in gastric antrum of diabetic rats

目的 探讨氮能神经在糖尿病大鼠胃运动障碍中的作用。方法 5 0只大鼠随机分为正常对照组 (n =2 0 )和糖尿病模型组(n=30 ) ,用链尿佐菌素建立大鼠糖尿病模型 ,3个月后记录两组的胃电活动并行胃窦肌间神经丛氮能神经计数。结果 糖尿病模型组胃电节律失常明显增加 ,异常节律指数 (ARI)和慢波频率变异系数 (CV)显著增高 ,胃窦肌间神经丛氮能神经细胞数明显减少 ,但氮能神经神经节数目无明显改变。结论 糖尿病大鼠胃窦肌间神经丛氮能神经改变可能是导致其胃电节律失常和胃运动障碍的原因之一。

Objective To study the role of nitriergic nerves in the myenteric plexus of the gastric antrum in diabetic rats with motor disorder. Methods Rats were randomly divided into diabetic group and control group. Electrogastrogram was recorded, and the number of cholinergic nerves in the myenteric plexus of the gastric antrum was counted 3 months after reproducing diabetes in the model group. Results In the rats of diabetic group, gastro-electric dysrhythmia was observed more frequently, and the number of nitriergic cells in the myenteric nerves was significantly decreased compared with control group. Conclusion The changes in nitriergic nerves in the myenteric plexus of the gastric antrum might be one of the mechanisms of gastro-electric dysrhythmia and gastric motility disorders in diabetic rats.