继发免疫性不孕与终止妊娠方式间的关系

The relationship secondary infertility of immune factor and the sorts of abortion

目的 :分析免疫性因素与终止妊娠方式间的相关性。方法 :对 2 0 6例非自然流产组、72例自然流产组人群进行抗精子抗体 (AsAb)、抗子宫内膜抗体 (EmAb)和抗心磷脂抗体 (ACL)检测 ,AsAb检测采用试管一玻片凝集试验 ,EmAb、ACL采用ELISA法 ,并以 4 5例正常生育妇女 (对照组 )作对照。结果 :生殖免疫性抗体为终止妊娠后引起继发不孕的主要原因之一( 4 1 75 % ) ;非自然流产组EmAb的产生率和自然流产组相比无差异性 (P >0 0 5 ) ,非自然流产组和自然流产组与正常生育组相比 ,免疫抗体的产生均有显著性差异 (P <0 0 0 1)。药物流产组EmAb的产生率高于人工流产组 (P <0 0 5 ) ;药物流产十清宫术组中EmAb的产生率最高 ( 6 2 5 0 % )。免疫性抗体的产生与流产次数多少不成比例。结论 :生殖免疫性抗体为终止妊娠后引起继发不孕的主要因素之一 ,药物流产方式EmAb的产生率高于人工流产组 ;

Objective:To investigate the relationship between secondary infertility of immune factor and the sorts of abortion.Methods:The sera of 206 secondary infertility women who made artificial abortion,and 72 had had Spontaneous abortion,were detected sera antisperm antibody (AsAb),antiendometrium antibody (EmAb),anticardiolipin antibody (ACL).45 normal pregnant (as control group) were observed.AsAb with Franklin-Dukes,EmAb、ACL with ELISA.Results:Anti-reproductive antibodies is one of the main reason for female infertility after artificial abortion(41 75%);There are significant difference compare control group with artificial abortion group and spontaneous abortion group ( P <0 001) ;There is no significant between EMAb in artificial abortion group and in spontaneous abortion group( P >0 05).EMA in artificial abortion group is lower than those in drug abortion group( P <0 05).EMAb in drug abortion and adding complete curettage of uterine cavity is the highest(62 50%).Anti-reproductive antibodies isn't relatived to abortion times.Conclusion:Anti-reproductive antibodies is one of the main reason for female infertility after artificial abortion;EMAb in drug abortion group is higher than those in artificial abortion;Anti-reproductive antibodies isn't relatived to abortion times.