低密度脂蛋白受体基因AvaⅡ多态性与心肌梗死的关系研究

Relationship between AvaⅡ polymorphism of the LDL receptor gene and acute myocardial infarction

目的 :探讨动脉粥样硬化致心肌梗死 ( AMI)与低密度脂蛋白受体基因( LDL- R) Ava 多态性的关系。方法 :用聚合酶链反应 ( PCR)技术检测 1 1 3例健康人和 81例 AMI患者的 LDL - R基因 Ava 多态性及血脂的含量。结果 :LDL- R基因 Ava 等位基因频率健康人 A+ 为 0 .2 30 ;AMI组 A+ 为 0 .32 7。 AMI组与对照组比较 LDL- R基因 Ava 多态性 A+ 型等位基因频率明显增高 ( P<0 .0 5 ) ;血清 TC、L DL- C、TG及 L P( a)水平亦明显增高 ( P<0 .0 1 )。结论 :Ava 多态性的 A+ 型等位基因可能与 AMI密切相关。

Objective:To investigate the relationship between AvaⅡ polymorphism of LDL receptor gene (LDL-R) and acute myocardial infarction of the Han nationality in Liaoning province. Methods:The polymerase chain reaction (PCR) technique was used to study the polymorphisms of LDL-R gene and allele frequencies in 81 patients with AMI and 113 age-matched Chinese healthy controls .The levels of the lipid and lipoproteins were also compared between the cases with AMI and the controls. Results :A + frequency of LDL-R gene in healthy controls and AMI group was 0.230 and 0.327 respectively. The frequency of the genotype A +A + (AvaⅡ) was greater in AMI group compared to the controls;in the AMI group A +A + genotype was associated with high concentrations of total cholesterol and LDL-C,TG, LP(a) in serum . Conclusion: The existence of A +A + can affect the concentration of serum lipid level and may be closely related to the occurrence of AMI.