CD_(44)V_6基因在前列腺癌组织中的表达及其意义

Expression and significance of CD_(44)V_6 gene in prostate cancer tissue

目的 探讨CD4 4V6 基因与前列腺癌 (PCa)的发生、转移及预后的关系。方法 采用S P免疫组织化学方法检测 82例PCa组织中CD4 4V6 基因的表达情况。结果 CD4 4V6 基因在前列腺癌中有较高的表达 ,阳性率为 46 3 % (38/82 ) ,其中伴盆腔淋巴结转移或骨转移者阳性率为62 5 % (1 5/2 4 ) ,无转移者阳性率 37 9% (2 3/58) ,两者具有显著性差异 (P <0 0 1 )。CD4 4V6 在PCa组织中的高表达还与癌组织的Gleason评分及预后有关 (P <0 0 5)。结论 具有CD4 4V6 高表达的PCa具有更强的浸润和转移能力 ,恶性度较高 ,分化较差 ,CD4 4V6 可作为判断预后及指导术后治疗的一项重要指标。

Objective To study the relationship between CD 44 V 6 expression in prostate cancer tissue and metastasis and prognosis.Methods The expression of CD 44 V 6 gene was detected in 82 cases of prostate cancer with S-P immunohistochemical method. Results The positive rate of CD 44 V 6 expression in prostate cancer tissue was 46.3% (38/82). Among them, the positive rate was 62.5% (15/24) in the prostate cancer patients with lymph node or bone metastasis, was 37.9 (23/58) in patients without metastasis, and the difference in the two situation was significant (P<0.01). The expression of CD 44 V 6 was correlated with the core of Gleason and prognosis of prostate cancer. Conclusions The CD 44 V 6 over-expression promoted the invasion and metastasis of prostate carcinomas. CD 44 V 6 expression was valuable to evaluate the prognosis and guide clinical treatment of prostate cancer.