以压灸百会穴为主治疗对椎动脉型颈椎病患者血栓素A_2和前列环素的影响

Effect of pressed acupuncture at baihui acupoint on thromboxane A_2 and prostacyclin in treating vertebral artery type of cervical spondylosis

目的:探讨压灸百会穴为主治疗椎动脉型颈椎病(CSA)的疗效。方法:采用随机单盲对照法将广州中医药大学收治的34例椎动脉型颈椎病患者分为两组,其中治疗组17例,予以压灸百会穴及局部电针法,对照组17例,采用单纯局部电针法,观察其临床疗效,并测定其治疗前后血浆血栓烷B2(TXB2)、6-酮前列腺素F1α(6-keto-PGF1-α)含量变化及K/T值。结果:治疗组痊愈9例,显效6例,好转2例,无效0例;对照组痊愈4例,显效6例,好转5例,无效2例。治疗组血栓烷B2、6-酮前列腺素F1α治疗前的值分别为(442.96±164.11),(157.01±75.43)ng/L治疗后为(144.22±127.81),(368.85±117.09)ng/L,对照组治疗前、后分别为(383.25±210.75),(156.39±84.15)ng/L和(198.72±141.65),(258.78±85.25)ng/L,两组与治疗前相比,差异有显著性意义(t=-4.01,-3.2,5.92,6.27,P<0.01),治疗组治疗后与对照组相比差异也有显著性意义(t=-2.19,3.13,P<0.01)。结论:压灸百会为主能有效改善椎动脉型颈椎病患者的临床症状,起到舒张血管压力的作用。

AIM: To explore the curative effect of pressed acupuncture mainly at the baihui acupoint on vertebral artery type of cervical spondylosis (CSA).METHODS: Totally 34 CSA patients,who were treated in the Guangdong University of Traditional Chinese Medicine,were randomly divided into two groups: treatment group(n=17) and control group(n=17).All the patients were treated with local electroacupuncture, and besides, those in the treatment group received pressed acupuncture at the baihui acupoint. The clinical curative effects were observed, the changes of contents of plasma thromboxane B2(TXB2) and 6 keto prostaglandin 1 alpha (6 keto PGF1α) and the ratio of them were determined before and after treatment in both groups.RESULTS: The number of cases with cure, significant effect, improvement and without effect was 9, 6, 2 and 0 respectively in the treatment group, but 4, 4, 7 and 2 in the control group respectively, and the curative effect in the treatment group was obviously better than that in the control group (χ2=6.58,P=0.025). The TXB2 and 6 keto PGF1αcontents in the treatment group before treatment were(442.96±164.11) and (157.01±75.43) ng/L, after treatment were (144.22±127.81) and (368.85±117.09) ng/L, while those in the control group before treatment were (383.25±210.75) and(156.39±84.15),after treatment were(198.72±141.65) and(258.78±85.25) ng/L,there were significant differences before and after treatment in both groups(t=5.92,6.27,3.0,3.52, P< 0.01). The content of 6 keto PGF1αafter treatment in the treatment group was significantly different from that in the control group (t=3.13, P< 0.01). CONCLUSION: Pressed acupuncture mainly at the baihui acupoint can effectively ameliorate the clinical symptoms of CSA patients, so as to diastole the vascular pressure.