肝硬化患者血激素水平的变化

The study on the changes of blood hormone in patients with cirrhosis

目的 研究肝硬化患者血激素水平的变化。方法 选取肝硬化患者 3 0名 (研究组 ) ,慢性肝炎患者 10名 (对照组 ) ,进行肝功能、腹部B超、核素心肝血流比检查 ,化验血肾上腺素、去甲肾上腺素、肾素、血管紧张素、醛固酮、心钠素、胰高糖素、内皮素、降钙素基因相关肽。结果 肝硬化患者血肾上腺素、去甲肾上腺素值较慢性肝炎患者升高 ,两者差异有显著性 (P <0 0 5 )。两组肾素、血管紧张素、醛固酮、心钠素、胰高糖素、内皮素、降钙素基因相关肽值差异无显著性 (P >0 0 5 )。ChildA级、ChildB级、ChildC级肝硬化患者血肾上腺素、去甲肾上腺素差异有显著性 (P <0 0 5 )。不同门静脉压力、不同病程、不同腹水量肝硬化患者血肾上腺素、去甲肾上腺素差异无显著性 (P >0 0 5 )。结论 肝硬化患者血肾上腺素、去甲肾上腺素值升高 ,并与肝功能损害程度有关 ,与病程、门静脉压力。

Objective To study the changes of blood hormone in patients with cirrhosis. Methods A total of 30 liver cirrhosis patients(study group) and 10 chronic hepatitis patients(control group)were examined by abdominal ultrosonography ,and liver function and H/L were tested. Blood E (epinephrine),NE (norepinephrine),R(rennin),A (angiotensin), Aldo(aldosterone), ANP(atrialnatrureticpolypeptide),G(glucagon), ET(endothelin) and CGRP(calcitonin gene related protein) were measured.Results There was significant difference in epinephrine,norepinephrine levels between cirrhosis patients and chronic hepatitis patients (P<0.05). There were no significant differences among the A(angiotensin),Aldo(aldosterone),ANP(atrial natruretic polypeptide),G(glucagon),ET(endothelin),CGRP(calcitonin gene related protein)of two groups(P>0.05) .There were significant differences among the epinephrine,norepinephrine of Child A、 Child B、 Child C cirrhosis patients(P<0.05) .Conclusions Levels of epinephrine and norepinephrine in cirrhosis patients obviously increase, and there is a positive relation between the levels of E,NE and liver function.