硫普罗宁对肝细胞损伤疗效的对照研究与临床评价

Comparative analysis of the therapeutic effects of tiopronin and its clinical evaluation on patients with liver damage

目的 探讨硫普罗宁对各种肝损伤的治疗效果。方法 各种病毒性肝炎 ,药物性、酒精性、肿瘤放、化疗后的各种肝损伤 2 2 0例 ,随机分为两组。对照组 110例 ,以肌苷 0 6g ,维生素C 2 0g ,维生素B60 2g加入 5 %葡萄糖溶液中静滴 ,每天 1次 ,连续治疗 3周 ;治疗组 110例 ,以硫普罗宁 0 2g加入 5 %葡萄糖液中静滴 ,每天 1次 ,连续治疗 3周 ,同时分别监测肝功能指标谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、总蛋白 (TP)、总胆红素 (TBi)、总胆汁酸 (TBA)等 ,并进行比较。结果 硫普罗宁治疗组较对照组在肝功能复常方面显示良好的治疗效应 ,使转氨酶明显下降 ,两组显效率分别为 5 0 % ( 5 5 /110 )和 3 0 % ( 3 3 /110 ) ,总有效率为 84% ( 92 /110 )和 5 0 % ( 5 5 /110 ) ,两组比较差异有显著性 (P <0 0 1)。结论 短期临床研究资料提示硫普罗宁治疗肝损伤 ,可明显改善肝脏功能 ,且副作用少 。

Objective To explore the therapeutic effects of tiopronin on different kind of liver damage. Methods 220 cases with liver damage due to viral hepatitis, drug hepatitis, alcohol hepatitis and after radiotherapy or chemotherapy to tumor patients were divided randomly into two groups on the average. The control group was treated by inosinum 0.6 g, (vitamin) C 2.0 g and vitamin B_6 0.2 g with intravenous drip once a day for three weeks. The treatment group was treated by (tiopronin) 0.2 g with intravenous drip once a day for three weeks, and liver function including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the levels of serum total protein (TP), total bilirubin (TBi), and total bile acid (TBA) were measured respectively. The results of two groups were compared. Results The therapeutic effects of the treatment group were evidently prior to the control group in recovering liver function and the clinical symptoms imp roved obviously in treatment group. Treatment with the drug was associated with a significant improvement in abnormalities of serum transaminase. The obvious effective rates were 50%(55/110) in the treatment group, and 30%(33/110) in the control group, respectively. The total effective rates were 84%(92/110) in the former and 50%(55/110) in the later, respectively. Significant difference in therapeutic effects was found between the two groups (P<0.01). Conclusions The present data suggest that tiopronin improves the liver function with few side-effects and has a good therapeutic effect on patients with liver damages during short-term study.