摘要
目的 :通过动物实验验证并探索补气益肾祛瘀法治疗良性前列腺增生症的机理。 方法 :手术法建立大鼠慢性膀胱颈梗阻模型 ,以中药益肾通方灌胃 ,观察三组 (治疗组 ,对照组 ,空白组 )膀胱平滑肌组织 ,分别作光镜及电镜检查并摄片比较。 结果 :造模组膀胱壁组织在光镜下以及电镜下 ,其组织形态结构均发生缺氧变性的病理改变 ,治疗组形态变化及平滑肌细胞形态表现均介于空白组与造模组之间。 结论 :益肾通方对慢性膀胱颈梗阻情况下对抗逼尿肌细胞缺氧变性以及延缓逼尿肌微观结构的病理变化方面 。
Objective To evaluate the mechanism of treatment by Yishentong prescrioption(based on traditional Chinese medicne treatment principle:tonify kidney enhance Qi and remove stasis)on benign prostatic hyperplasia(BPH) through animal model experiment Methods The changes on cells of detrusor musculature on three rats groups(normal group,treatment group and model group)were observed by light microscopy and electro microscopy.Results The pathological(anoxic and metamorphic)changes on the cells in the treatment group were milder than those in the model group. Conclusion The therapeutic mechanism of Yishentong on BPH may be antioxidation and metamorphologic alleviation on the ultrastructure of detrusor musculature which will impair the constriction of the detrusor after chronic bladder outlet obstruction.
出处
《中国中西医结合外科杂志》
CAS
2004年第5期367-369,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
国家中管局重点课题科研基金资助 ( 97A2 0 2 )
