摘要
红霉素A硫氰酸盐与盐酸羟胺缩合成红霉素A-9-肟,在相转移催化下与甲氧乙氧氯甲醚成肟醚得罗红霉素。
Roxithromycin was synthesized from erythromycin A thiocyanic acid salt through erythro mycin A O oxime with 2 methoxyethoxymethyl chloride (MEM chloride) by phase transfer catalyst TBAB. This method provided with low costs and a moderate reaction condition, and was suitable for mass production.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2004年第10期588-589,共2页
Chinese Journal of Antibiotics
基金
河南大学科研基金资助项目(XK02041)。
关键词
抗生素
红霉素A
罗红霉素
相转移催化
Antibiotics
Roxithromycin
Erythromycin A
Phase transfer catalysis
