急性颅脑损伤后脑脊液内皮素和一氧化氮的浓度变化及意义

Clinical significance of CSF ET and NO changes in acute craniocerebral trauma

目的测定急性颅脑损伤患者脑脊液内皮素(ET)、一氧化氮(NO)的含量,探讨其在颅脑损伤中的作用机理。方法按GCS评分分组(≤8分为重伤组,>8分为轻伤组),对42例急性颅脑损伤患者于伤后不同时期(伤后24h,3、5、7d)测定脑脊液中ET、NO含量,并评定其与预后的关系。结果重伤组患者伤后脑脊液ET、NO含量显著高于轻伤组(P均<0.05)。脑脊液ET、NO峰值越高,预后越差(P<0.01)。结论ET、NO参与了急性颅脑损伤后病理生理变化,监测其含量变化,对于伤情判定及临床治疗有重要意义。

Objective To study the role of cerebrospinal fluid (CSF) endothelin (ET) and NO in craniocerebral injury in patients with acute craniocerebral trauma by determination the contents of CSF ET and NO from the patients. Methods Forty-two cases with acute craniocerebral trauma were divided into two groups by their GCS scores (GCS≤8 group and GCS>8 group). Contents of CSF ET and NO of the patients at different time (the first day, the third day, the fifth day and the seventh day after injuries) were determined, and a comparison between these two groups was done and evaluating the relationship to the prognosis. Results The contents of CSF ET and NO in GCS≤8 group were higher than those in GCS>8 group, respectively (all P<0.05). The higher the CSF ET and NO values were, the worse the prognosis were (P<0.01). Conclusion ET and NO are involved in the pathologic and physiological courses and have an important significance in treatment and diagnosis of acute craniocerebral injury.