低温脑保护仪对失血性休克家兔的保护效应

Effects of the hypothermic brain-protection apparatus on rabbits with hemorrhagic shock

目的 探讨低温脑保护仪对失血性休克的保护作用。方法 采用改良Wigger’s休克模型 ,观察自行研制的低温脑保护仪对休克动物的存活时间及生命功能指标的影响。结果 与对照组相比 ,低温脑保护仪能降低脑组织 60 %脂质过氧化物的产生 ,减缓心率和呼吸 ,从而降低氧耗。结论 低温脑保护仪能有效减轻脑组织损伤 ,显著延长休克动物存活时间。

Objective To study the protective effect of the hypothermic brain-protection apparatus on hemorrhagic shock rabbits. Methods Applying the modified Wigger's shock animal model, we observed the effects of a self-developed brain-protecting apparatus on the survival time and vital signs of rabbits. Results Hypothermic brain protection could considerably reduce 60% lipid hyperoxide in brain tissues as compared with that in the control group. It could also decrease heart rate and respiration and hence reduce tissue oxygen consumption. Conclusion Hypothermic brain protection can attenuate the brain lesion and obviously prolong the survival time of hemorrhagic shock animals.