组织工程化口腔黏膜载体材料聚乳酸羟基乙酸膜的制作及物理特性

Preparation and Properties of PLGA Membrane for Oral Tissue-engineered Mucosa

目的 制作组织工程化口腔黏膜载体材料,研究其物理特性。方法 不同比例的聚乳酸(PLA)和聚乙醇酸(PLG)按常规成膜技术制备聚乳酸羟基乙酸(PLGA)。测定其孔隙率,倒置相差显微镜和电子扫描显微镜(SEM)观察其物理特性。结果 PIGAⅠ、Ⅱ、Ⅲ为平滑透明膜,孔隙率10.56％、18.24％、8.64％,SEM观察呈现数目不等微孔和纤维交织样结构;PIGAⅠV及改性膜不透明,较脆,孔隙率为56.39％左右,SEM观察为泡孔网海绵状。结论 PLGA Ⅰ、Ⅱ、Ⅲ具较好的透明度及孔隙率,可被用作组织工程化口腔黏膜载体材料。

Objective To construct polycledeclide-co - plycolide(PLGA)membranes and study their physical properties. Methods A series of PLGA membranes were constructed with different proportions of poly- L- Lactic acid and polyglycolic acid,and the porous rates and physical properties of PLGA were studied. Results PLGA Ⅰ, Ⅱ , Ⅲ were transparent membranes with porous structure, and their porous rates were 10.56% , 18.24% , 8.64% .respectively;PLGA Ⅳ and other membranes were fragile and not transparent membranes with spongy structure, and porous rates was 56.39% . Conclusion PLGA membranes we made were ideal materials for oral tissue - engineered mucosa due to their good physical properties.