两种剂量免疫球蛋白治疗川崎病疗效探讨

Treatment of Kawasaki disease with intravenous immuneoglobulin in two different doses

目的 :探讨不同剂量免疫球蛋白 (IVIG)静脉滴注治疗小儿川崎病的疗效。方法 :回顾性总结 1995～ 2 0 0 3年收治的4 1例川崎病患儿治疗情况。结果 :17例川崎病应用IVIG 1g/kg ,分 4 0 0～ 5 0 0mg·kg-1·d-1× 2～ 3天和 2 2例IVIG 2g/kg ,分 4 0 0mg·kg-1·d-1× 5天治疗 ,在退热时间、白细胞下降至正常、冠状动脉 (CA)扩张等方面差异均无显著性 (P =1.0 0 0 )。结论 :IVIG治疗小儿川崎病 ,1g/kg和 2g/kg疗效相当 ,推荐应用IVIG 1g/kg 。

Objective:To explore the efficacy of different doses' of IVIG in treatment of Kawasaki disease.Methods:The data of 41 cases of Kawasaki disease admitted to our hospital from 1995 to 2003 were reviewed.Results:Seventeen cases were treated with IVIG 1g/kg(400-500 mg·kg -1·d -1,for 2-3 days).22 cases with IVIG 2 g/kg(400 mg·kg -1·d -1 for 5 days).There was no obvious difference between the two groups(P=1.000) in the lasting time of fever,blood white cell count,and coronary artery dilation(CAD).Conclusions:The efficacy of two different dose of IVIG is almost equal in treatment of Kawasaki disease.We suggest that 1 g/kg IVIG be used to save the drug resource and reduce the cost.