大剂量丙种球蛋白治疗小儿重症病毒性脑炎临床分析

Clinical analyses of high dose immunoglobulin in treatment of severe viral encephalitis in children

目的 :观察静脉滴注大剂量丙种球蛋白 (HDIG)治疗小儿重症病毒性脑炎 (SVE)的临床疗效。方法 :38例SVE分为HDIG治疗组 16例和对照组 2 2例 ,治疗组在对照组常规治疗的基础上静脉滴注HDIG(4 0 0mg·kg-1·d-1) ,并观察患儿的临床症状、体征消失的时间及住院时间。结果 :治疗组止痉时间、神志开始恢复时间、退热时间短于对照组 (P <0 .0 5～P <0 .0 1) ,住院时间与对照组差异无显著性 (P >0 .0 5 )。结论 :HDIG治疗SVE能减轻脑组织损害 ,缩短疗程 。

Objective:To evaluate the efficacy of high dose immunoglobulin in treatment of severe viral encephalitis in children.Methods:Thirty-eight children were divided into study group(n=16) treated with intravenous high dose immunoglobulin and control group(n=22).The clinical symptoms,physical signs and the time of hospital stay were observed and compared.Results:It took less time for the study group to bring down a fever,stop spasm and regain consciousness than it did for the control group(P<0.05 to P<0.01),and no difference was found in the time of hospital stay between the two groups(P>0.05).Conclusions:Intravenous high dose immunoglobulin can relieve brain tissue damage and is effective in treating severe viral encephalitis of children.