摘要
目的:探讨微量元素硒对大鼠慢性胃炎的预防作用。方法:用60％乙醇联合脱氧胆酸钠经口灌服制备大鼠慢性胃炎模型,每日经口灌服亚硒酸钠40 μg/200g bw,观察预防作用。测定大鼠胃液成分,用荧光法测定全血和胃粘膜谷胱甘肽过氧化物酶活性和血硒、胃粘膜硒及肝组织硒的含量。采用改良李氏法测定胃蛋白酶活性。结果:硒预防组大鼠胃液的pH值明显下降,游离酸量显著高于模型组(P<0.01),而胃蛋白酶活性明显低于模型组(P<0.01);全血和胃粘膜谷胱甘肽过氧化物酶活性显著增高(P<0.01);血硒、胃粘膜硒及肝组织硒水平显著高于模型组,接近正常对照组。结论:微量元素硒对乙醇联合胆汁酸盐引起的大鼠慢性胃炎有一定的预防作用。
Objective: To study the preventive effect of selenium on chronic gastritis in rats. Methods: The experimental model for chronic gastritis was induced by intragastric administration of 60% alcohol and drinking water containing 10 mmol/L sodium deoxycholic acid in rats . Sodium selenite 40 μg/ (200 g bw·d) was administered through oral. The GSH-Px activity and selenium content in blood and liver and the pepsin activity were determined . Results: In selenium group the pH of gastric juice clearly reduced, free acid content increased and the pepsin activity also decreased . The content of selenium increased remarkably in blood and gastric mucosa as well as in liver . GSH-Px activity in blood and gastric mucosa increased significantly. Conclusion: Selenium has the preventive effect on chronic gastritis induced by alcohol combined with sodium deoxycholic acid.
出处
《营养学报》
CAS
CSCD
北大核心
2004年第5期348-350,353,共4页
Acta Nutrimenta Sinica
关键词
亚硒酸钠
脱氧胆酸钠
乙醇
慢性胃炎
sodium selenite
sodium deoxycholic acid
alcohol
chronic gastritis
