塞来昔布致重症多形性红斑和肝损害

Stevens-Johnson syndrome and liver damage after celecoxib therapy

A 30-year-old man was diagnosed as "myofascitis" and treated with celecoxib 200mg once daily. On day 3 he developed multiple skin lesions with pruritus and pain on his abdomen, and stopped celecoxib immediately. The skin rash was increased progressively and distributed over trunk, legs and arms, then feet and face. The skin lesions were expanded and partially fused. Then the patient was treated with intravenous infusion of dexamethasone 10mg daily. 3 days later,pruritus was decreased but skin pain was increased. Thenthe man was treated with intravenous infusion of 10% calcium gluconate 20ml plus lotion calamine for 3 days. Illness condition unimproved, he was admitted to hospital. He had a history of hypersensitivity to sulfadiazine during childhood. Physical examination revealed mouth ulcers. The man was given dexamethasone,& 10% calcium gluconate, erythromycin, ciprofloxacin, and antihistamines plus lotion calamine during hospitalization. 10 days later, the symptoms lessened; 40 days later, the skin rash resolved gradually.