子宫内膜异位症及子宫腺肌症患者雌、孕激素受体研究

Study on Estrogen and Progesterone Receptors in Endometriosis and Adenomyosis

用葡聚糖—活性炭分离法(DCC)在18例卵巢宫内膜异位症患者的异位内膜组织及13例子宫腺肌症患者的局部腺肌组织中测得雌激素受体(ER)和孕激素受体(PR),但其阳性结果平均值低于正常宫内膜。18例卵巢宫内膜异位症中,PR阴性6例(33.4％),这可能与部分患者孕激素治疗效果不满意有关;13例子宫腺肌症中PR阳性10例(76.9％),提示对40岁以下患者保留子宫,采用激素治疗的可能性。雌、孕激素受体水平与这两种疾病患者的治疗及预后的关系,值得进一步探讨。

Estrogen and progesteronoreceptors (ER and PR) in 18 cases of ova-rian endometriosis and 13 cases of adeno-myosis were determined with dextran coatedcharcoal (DCC) method. The levels of ERand PR in those specimens were lowerthan those of normal endometrium. Amongthe 18 cases of ovarian endometriosis, 6(33.4%) were negative for PR, which ac-ounted for the unsatisfactory results of pro-gesterone treatment for some endometriosis.In the 13 cases of adenomyosis there were10 (76.9%) showing positive PR. It is sug-gested that the hormone therapy may beuseful to treat those young patients withadenomyosis instead of surgery. The correlation of the ER and PR levels,the treatment and prognosis in endometrio-sis and adenomyosis are worth furtherstudying.