摘要
报道6名青年健康志愿者口服环丙氟哌酸后的药代动力学研究结果。用反相高效液相层析法测定血、尿药物浓度,该药体内过程符合单室模型。单剂空腹口服该药片500mg后的平均峰浓度、达峰时间和药时曲线下面积分别为4.17±1.05mg/L,1.75±0.40h和18.09±2.69mg/L·h;其消除半衰期为2.34±0.81h,表观分布容积为3.71±0.75L。服药后24小时内尿中原型药排出量占给药量的34.22±6.57%。研究表明,该药具有吸收快、达峰迅速,血及尿中药物浓度高等特点。
Pharmacokinetic studies onciprofloxacin were carried out in 6 younghealthy volunteers. Serum and urinelevels of ciprofloxacin were measured byreversed-phase high performance liquidchromatography. The drug obeyed one-compartment model kinetics in serum.Themean peak serum concentration, time topeak concentration and the area under thecurve were 4. 17±1. 05mg/L, 1. 76±0. 40hand 18. 09±2. 69mg/L·h respectively afteroral administration of 500mg of ciprofloxa-cin tablet. The elimination half life was2. 34±0. 81h and the apparent volume ofdistribution was 3. 71±0. 75L. The urinaryrate of ciprofloxacin over 24h after dosingwas 34. 22±6. 57%. These data indicate thatciprofloxacin is easily absorbed and itsconcentration reaches the peak level rapi-dly. There are high levels of drug both inserum and urine.
出处
《华西医科大学学报》
CAS
CSCD
1993年第3期306-308,共3页
Journal of West China University of Medical Sciences
关键词
环丙氟哌酸
药代动力学
Ciprofloxacin
Pharmacokinetics
Reversed-phase high performance liquid chromatography