涎腺良恶性肌上皮肿瘤 DNA 含量与临床预后间关系的探讨

Study of the Relationship Between Clinical Prognosis and DNA Content of Benign and Malignant Myoepitheliomas of Salivary Glands

采用多功能图象分析技术对22例涎腺良、恶性肌上皮肿瘤进行 DNA 含量的研究表明,肌上皮瘤是一种以二倍体和近二倍体为主的肿瘤,在生物学行为上属于良性肿瘤;而肌上皮癌则以增殖倍体、高倍体和非整倍体为主,其增殖倍体大于50%;高倍体和非整倍体大于20%,是一种恶性度较高的肿瘤。良、恶性肌上皮肿瘤在核 DNA 含量上存在着明显的差异。作者讨论了 DNA 含量与临床预后之间的相互关系,并认为肿瘤中大于5C 细胞的数量是提示预后的客观指标。

DNA content was quantitaively determined in 22 cases of benign and malignant myoepitheliomas of salivaryglands by image analysis technique,the result indicated that myoepitheliomas were diploid and near—diploid tu-mors,whereas myoepithelial carcinomas were near—tetraploid,hyperdiploid and aneudiploid tumors,in which near—tetraploid>50%,hyperdiploid and aneudiploid>20%,it showed that myoepithelial carcinomas were much moremalignant tumors,there were great differences in DNA content between benign and malignant myoepitheliomas.The correlation between DNA content and clinical prognosis was discussed.It is suggested that the number of nu-clei more than 5C DNA may be an objective index pointing to a poor clinical prognosis.