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PKCθ在T细胞活化和IL-2表达中的作用 被引量:2

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摘要 蛋白激酶C作为一种丝氨酸苏氨酸激酶在T细胞活化过程中起重要作用。然而,是PKC家族中哪个成员起主要作用,以及具体的作用机制都不清楚。90年代初,随着新型PKC异构型PKCθ的克隆成功,对于PKCθ在T细胞功能活化中的重要作用的认识也逐步加深。本文将主要就PKCθ在T细胞活化及IL2表达过程中作用的研究进展作一综述,并简要提及PKCθ在T细胞中的其他作用。
出处 《国外医学(免疫学分册)》 CAS 2004年第6期346-350,共5页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
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  • 1Banan A,Zhang LJ,Shaikh M,et al.Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium:a novel function for PKC-theta[J].Am J Physiol Cell Physiol,2004,287(1):218-234.
  • 2Isakov N, Altman A.Protein kinase C (theta) in T cell activation[J].Annu Rev Immunol,2002,20:761-794.
  • 3Villalba M,Altman A.Protein kinase C-theta (PKC theta),a potential drug target for therapeutic intervention with human T cell leukemias[J].Curr Cancer Drug Targets,2002,2(2):125-137.
  • 4Altman A,Villalba M.Protein kinase C-theta (PKC theta):a key enzyme in T cell life and death[J].J Biochem (Tokyo),2002,132(6):841-846.
  • 5Villalba M,Bushway P,Altman A.Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD[J].Immunol,2001,166(10):5955-5963.
  • 6Baier G.The PKC gene module:molecular biosystematics to resolve its T cell functions[J].Immunol Rev,2003,192(4):64-80.
  • 7Dennehy KM,Kerstan A,Bischof A,et al.Mitogenic signals through CD28 activate the protein kinase C theta-NF-kappaB pathway in primary peripheral T cells[J].Int Immunol,2003,15(5):655-663.
  • 8Southwell BR.Localization of protein kinase C theta immunoreactivity to interstitial cells of Cajal in guinea-pig gastrointestinal tract[J].Neurogastroenterology & Motility,2003,15(2):139-148.
  • 9Pfeifhofer C,Kofler K,Gruber T,et al.Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells[J].J Exp Med,2003,197(11):1525-1535.
  • 10Altman A,Isakov N,Baier G.Protein kinase Cθ:a new essential superstar on the T-cell stage[J].Immunol Today,2000,21(11):567-573.

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