卒中平对动脉硬化性脑梗塞患者血浆TXB_2和6-酮-PGF_(1α)含量的影响

THE EFFECTS OF STROKE-SUPPRESSION ON THE PLASMA TXB_2 AND 6-KETO-PGF_(1a) LEVELS OF THE PATIENTS WITH ARTERIOSCLEROSTIC CEREBRAL INFARCTION

本文采用卒中平,一种在我国古方基础上经科学筛选后组成的并经临床证实对治疗脑梗塞有确切疗效的纯中药制剂,治疗23例急性动脉硬化性脑梗塞患者,以观察对治疗前后血浆TXB_2和6-酮-PGF_(1α)含量的影响。结果表明治疗后患者血浆中TXB_2含量显著下降(P<0.05)。提示卒中平治疗脑梗塞的途径之一可能是通过降低血浆TXA_2,调节PGI_2-TXA_2失衡状态,减轻TXA_2对中枢神经系统的损害而实现的。

23 patient s with arteriosclerostic cerebral infarction were treated by stroke-suppression. The data showed that the plasma TXB_2 le-vels of these patients were decreasedafter treatment. But the plasma 6-keto-PGF_1. levels were no significant cha-nge. We suggest that the therapeuticeffeciency of stroke-suppression on thepatients with arteriosclerostic cerebralinfarction may be related to the modi-fied effect of the plasma TXA_2 andPGI_2 levels.