摘要
目的 :实验研究小剂量顺铂对放疗诱导 Hela细胞凋亡的作用。方法 :将细胞分为空白对照组、单纯化疗组、单纯放疗组、放疗加化疗组 4组 ,采用 TUNEL 法分别检测各组细胞的凋亡率。结果 :单纯放疗、化疗都可诱导 Hela细胞凋亡 ,顺铂 (化疗 )可以明显增强放疗诱导的细胞凋亡。结论 :小剂量顺铂可明显增加放疗诱导的 Hela细胞凋亡 。
Objective:To study the effects of low dose of cisplatin on Hela cell apoptosis induced by radiotherapy( RT).Methods:The Hela cells were divided into four groups: control group ,RT alone,chemotherapy(ChT) alone and RT combined with ChT group .The apoptosis rate of Hela cell was detected by a modified in situ TUNEL technique .Results:RT and ChT could induce Hela cell apoptosis and cisplatin(ChT) could obviously enhance Hela cell apoptosis induced by RT. Conclusion:Low dose of cisplatin can obviously enhance Hela cell apoptosis, induced by RT,providing academic proof for clinical use of low dose of cisplatin to enhance cell apoptosis induced by RT.
出处
《黑龙江医药科学》
2004年第5期19-20,共2页
Heilongjiang Medicine and Pharmacy