摘要
测定28例缺氧性肺动脉高压患者和23例正常人的血管紧张素Ⅰ、Ⅱ(ATⅠ及ATⅡ)及血管紧张素转化酶(ACE),并对其中8例患者进行了巯甲丙脯酸治疗试验。结果显示缺氧性肺动脉高压患者与正常对照组相比,其血浆ATⅡ水平明显升高,血清ACE活性明显降低;常规疗法对降低患者的ATⅡ水平和平均肺动脉压(mPAP)的作用不大,而加用巯甲丙脯酸后可使ACE活性进一步降低,从而明显降低ATⅡ和mPAP。由此表明ATⅡ在缺氧性肺动脉高压的发病中起着重要的作用,而巯甲丙脯酸则可能是一种治疗该症的有效药物。
The levels of angiotensin Ⅰ,Ⅱ (ATⅠ, Ⅱ)and angiotensin convertingen-zyme (ACE) were measured in 28 patie ntswith hypoxic pulmonary hypertensionand 23 normal individuals. The effects ofcaptopril were observed in 8 of 28 patients.The results showed that the average levelof ATⅡ in the patients was significantlyhigher than that in normal control (P<0.05), but the average level of ACE in thein the controls (P<0.05). In 8 patients,after the use of captopril, an ACE inhibi-tor, for two weeks, the levels of ATⅡ,ACE and mean pulmonary arterial pres-sure (mPAP)were markedly decreased (P<0.05). But the other 20 patients treatedwith antibiotics, antiasthmatics, diureticsand oxygen therapy for two weeks did notshow any alterations in the levels of ATⅡ,ACE and mPAP.
出处
《华西医科大学学报》
CSCD
1993年第2期228-231,共4页
Journal of West China University of Medical Sciences
关键词
肺动脉高压
血管紧张素
转化酶
Pulmonary hypertension
Angiotensin
Angiotensin converting enzyme
Captopril