MMP-2和MMP-9表达与卵巢上皮性癌侵袭转移的关系

Relation between expression of MMP-2 and MMP-9 and invasion, metastasis of epithelial caranoma of ovary

目的 研究基质金属蛋白酶(MMP-2和MMP-9)在卵巢上皮性癌组织中的表达,探讨MMP-2、MMP-9表达与肿瘤的侵袭转移及预后的关系。方法 用免疫组化S-P法对47例卵巢上皮性癌组织中MMP-2和MMMP-9的表达情况进行检测。结果 MMP-2和加MMP-9的表达在卵巢上皮性癌各组织类型之间差异无显著性,但在临床分期、初发、复发及细胞分级之间差异有显著性。MMP-2和MMP-9的表达与生存时间呈负相关。结论 MMP-2、MMP-9与卵巢上皮性癌的侵袭转移及预后有关。

Objective To study the expression of matrix metalloproteinases (MMP-2, MMP-9) in epithelial carcinoma of the ovary and to explore their relation to invasion, metastasis and prognosis. Methods The expression of MMP-2,MMP-9 in 47 epithelial ovarian carcinomas was investigated by the immunohistochemical method. Results There were no significant differences in the expression of MMP-2 and MMP-9 between different histologi-cal types of ovarian carcinomas, but significant difference in MMP-2, MMP-9 expression was found between different clinical stages,primary and relapse,different histological grades.There was negative correlation between the expression of MMP-2, MMP-9 and survival time. Conclusion The expression of MMP-2 and MMP-9 correlated with invasion, metastasis and prognosis of epithelial ovarian carcinomas.