多奈哌齐与多奈哌齐加银杏叶提取物合用治疗阿尔采末病的疗效比较

Donepezil alone vs donepezil combined with Gingko biloba extract in treatment of Alzheimer disease

目的 :比较多奈哌齐和多奈哌齐加银杏叶提取物合用治疗阿尔采末病 (AD)的疗效。方法 :4 2例AD病人分为 2组 ,多奈哌齐组 2 0例 [男性 17例 ,女性 3例 ,年龄 (70±s 7)a],给多奈哌齐 5mg ,po ,qd× 12wk ;多奈哌齐加银杏叶提取物组 [男性13例 ,女性 9例 ,年龄 (79± 6 )a],给多奈哌齐 5mg ,po ,qd× 12wk ,加银杏叶提取物 80mg ,po ,tid× 12wk。应用MMSE及ADL评定疗效。结果 :多奈哌齐组总有效率为 6 0 % ,联合用药组总有效率为 73% ,2组疗效比较差异无显著意义 (P >0 .0 5 )。结论 :多奈哌齐是一个治疗AD有效的药物 ,多奈哌齐加银杏叶提取物合用与单独应用多奈哌齐疗效近似。

AIM: To compare the effects of donepezil alone and donepezil combined with Gingko biloba extract in treatment of Alzheimer disease (AD). METHODS: Forty-two patients with AD were divided into two groups. Donepezil alone group of 20 patients (M 17, F 3; age (70±s7) a) received donepezil 5 mg, po, qd for 12 wk; donepezil combined with Gingko biloba extract group of 22 patients (M 13, F 9; age (79±6) a) received donepezil 5 mg, po, qd for 12 wk and Gingko bilba extract 80 mg, po, tid for 12 wk. Effects were evaluated with MMSE and ADL. RESULTS: The total clinical effective rates were 60 % for donepezil alone group and 73 % for donepezil combined with Gingko biloa extract group. There was no significant difference between two groups(P>0.05). CONCLUSION: Donepezil is a safe and effective drug in treatment of AD. The effect of donepezil combined with Gingko biloba extract is same to that of donepezil alone in treatment of AD.