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一种研制中的新型抗抑郁药——奈米非肽 被引量：3

A researching antidepressive agent——nemifitide
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摘要 奈米非肽是一种正在进行Ⅲ期临床试验的人工合成肽类抗抑郁药。本文概述了奈米非肽的药动学、药理作用机制以及临床试验情况。奈米非肽抗抑郁活性和安全性已得到临床证实。 Nemifitide is a synthetic peptide in the phase Ⅲ clinical trials. The article describes its pharmacokinetics, the mechanism of action, and clinical trials as an anti-depressant. So far, the anti-depressive activity and safety of nemifitide has been verified.
作者 朱颐申 韦萍 欧阳平凯
机构地区 南京工业大学制药与生命科学学院
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2004年第11期804-806,共3页 Chinese Journal of New Drugs and Clinical Remedies
关键词 抗抑郁药 药动学 临床试验 Ⅲ期 奈米 非肽 antidepressive agents pharmacokinetics clinical trial, phase Ⅲ nemifitide
分类号 R971.4 [医药卫生—药品]
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参考文献11

  • 1-[11]See above
  • 2NICOLAU G, FEIGHNER JP, REINER M, et al. Metabolism of the antidepressant nemifitide and its potential for drug interactions[J]. Int J Neuropsychopharmacol, 2002, 5 Suppl 1: S204.
  • 3MORRISON J, FEIGHNER JP, NICOLAU G, et al. Clinical pharmacokinetic studies with nemifitide, a novel pentapeptide antidepressant[J]. Int J Neuropsychopharmacol, 2002, 5 Suppl 1:S203-S204.
  • 4OVERSTREET DH, MATHE AA, NICOLAU G, et al. Effects of nemifitide on brain NPY levels and swim test immobility in a genetic animal model of depression [J]. Eur Neuropsychopharmacol, 2002, 12 Suppl 3: 242.
  • 5HLAVKA J, ABAJIAN H, MORRISON J, et al. Chemistry and pharmacology of nemifitide, a novel antidepressant pentapeptide[J]. Int J Neuropsychopharmacol, 2002, 5 Suppl 1:S97.
  • 6PORSOLT RD, le PICHON M, JALFRE M. Depression: A new animal model sensitive to antidepressant treatments[J]. Nature, 1977, 266: 730-732.
  • 7KELLY J, HARKIN A, NICOLAU G, et al. A preclinical investigation of the mechanism of action of nemifitide: A possible role for serotonin?[J]. Int J Neuropsychopharmacol, 2002, 5 Suppl 1:S97.
  • 8FEIGHNER JP, NICOLAU G, ABAJIAN H, et al. Clinical pharmacokinetic studies with INN 00835(nemifitide), a novel pentapeptide antidepressant[J]. Biopharm Drug Dispos, 2002, 23(1): 33-39.
  • 9FEIGHNER JP, EHRESING RH, KASTIN AJ, et al. A double-blind, placebo-controlled, efficacy, safety and pharmacokinetic study of INN 00835, a novel antidepressant peptide, in the treatment of major depression[J]. J Affect Disord, 2000, 61(1-2): 119-126.
  • 10FEIGHNER JP, SVERDIOV L, ABAJIAN H, et al. Pilot study with nemifitide in patients with severe treatment-resistant depression[J]. Int J Neuropsychopharmacol, 2002, 5 Suppl 1: S204.

同被引文献18

  • 1文彬,韩伟.选择性5-羟色胺再摄取抑制剂治疗抑郁症的应用现状[J].中国临床康复,2004,8(15):2952-2952. 被引量：8
  • 2周再丽,贾平.抗抑郁药物及其临床应用[J].中国医刊,2004,39(6):47-51. 被引量：27
  • 3European Directorate for the Quality of Medicines. European Pharmacopoeia 5.0 [ S ] .
  • 4国家药典委员会.中华人民共和国药典(2010版)[S].
  • 5Sanz-Nebot V, Garces A, Barbosa J. J Chromatogr A, 1999,833(2) : 267-275
  • 6Sanz-Nebot V, Benavente F, Barbosa J et al. J Chromatogr A,2000,870(2) :315-334
  • 7Sanz-Nebot V, Toro I, Barbosa J. J Chromatogr A, 1999, 846(1) :25-38
  • 8Schnolzer M, Jones A, Alewood P F. Anal Biochem, 1992,204(2) : 335-343
  • 9Engebretsen M, Agner E, Sandonsham J. J Pept Res, 1997, 49(4):341-346
  • 10Litowski J R, Semchuk P D, Mant C T. J Pept Res, 1999,54(1): 1-11

引证文献3

二级引证文献3

中国新药与临床杂志
2004年 第11期

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