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伊马替尼在胃肠道间质瘤治疗中的应用 被引量：5

Application of imatinib in treatment of gastrointestinal stromal tumour
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摘要 伊马替尼为苯胺嘧啶的衍生物 ,是一特异性的酪氨酸激酶抑制剂 ,合成于 1992年 ,2 0 0 1年 5月被FDA批准用于治疗慢性粒细胞白血病。最近 ,伊马替尼又被FDA批准用于治疗胃肠道间质瘤(GIST) ,本文主要综述该药的药效学、药动学以及在GIST治疗中的疗效、不良反应和耐受性。 Imatinib mesylate (imatinib) is derivative of 2-phenylaminopyrimidine, that is a special inhibitor of the tyrosine kinases which was synthesized in 1992. It was approved by the food and drug administration in USA for the treatment of chronic myeloid leukaemia (CML) in May 2001 and recently for unresectable and/or metastatic malignant gastrointestinal stromal tumour (GIST). This paper reviews the progress in the pharmacodynamics, pharmacokinetics, clinical effect of imatinib mesylate for the treatment of GIST and its adverse reactions and tolerance.
作者 尚雯 陶霞 刘皋林
机构地区 中国人民解放军第二军医大学附属长征医院药学部
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2004年第11期806-810,共5页 Chinese Journal of New Drugs and Clinical Remedies
关键词 胃肠肿瘤 药物疗法 药动学 伊马替尼 真肠遭间质瘤 gastrointestinal neoplasms drug therapy pharmacokinetics imatinib gastrointestinal stromal tumour
分类号 R979.1 [医药卫生—药品] R735.2 [医药卫生—肿瘤]
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参考文献22

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二级参考文献12

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同被引文献30

  • 1沈琳,金懋林.甲磺酸伊马替尼治疗复发或转移性胃肠间质瘤[J].中华肿瘤杂志,2004,26(11):697-699. 被引量：27
  • 2席吕刚,蔡端.胃肠道间质瘤35例诊治分析[J].中国实用外科杂志,2005,25(3):151-153. 被引量：27
  • 3苏庆革,石朝领,邢林厚,张华.上消化道恶性肿瘤首次胃镜检查误诊37例分析[J].临床误诊误治,2006,19(9):92-93. 被引量：4
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  • 6Seidman AD,Fornier MN,Esteva FJ,et al.Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification.J Clin Oncol,2001,19(10):2587-2595.
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  • 9Bende G, Kollipara S, Mowa S,et al. Validatiai an HPLC methodfor deteimination of imatinib mesylate in rat serum and its application ina pharmacokinetic sludy[j]. J Chromatogr Sci,2010,48(5) :334.
  • 10Parise RA, Ramanathan RK, Hayes MJ, et al. Liquid chromatographic-mass spectnxnetric assay for quantitaticm of imatinib and its main metabo-lite (CGP 74588) in plasma[j]. J Chrn?natogr B Analyt Technol BitmiedLifeSci,2003,791(l-2):39.

引证文献5

二级引证文献5

中国新药与临床杂志
2004年 第11期

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