艾司奥美拉唑、克拉霉素和阿莫西林三联疗法根除幽门螺杆菌的疗效

Effect on eradication of Helicobacter pylori with esomeprazole, clarithr-omycin and amoxicillin triple therapy

目的 :观察艾司奥美拉唑、克拉霉素和阿莫西林三联疗法根除幽门螺杆菌 (Hp)的疗效 ,以期寻找疗程短、疗效高的方案。方法 :10 1例Hp阳性病人随机分为 3组。治疗 1组 (31例 )予艾司奥美拉唑 2 0mg ,克拉霉素0 .5 g,阿莫西林 1.0 g ,疗程3d。治疗 2组 (35例 )予药物 ,剂量同治疗 1组 ,疗程 7d。对照组 (35例 )予奥美拉唑 2 0mg ,克拉霉素 0 .5 g ,阿莫西林 1.0 g ,疗程 7d。均每日 2次口服。停药 4wk查13C 尿素呼气试验。结果 :治疗1,2组 ,对照组Hp的根除率为 81% ,86 % ,83% ,均P >0 .0 5。不良反应发生率为 9% ,19% ,2 1% ,P >0 .0 5。C/E为 2 .5 2 ,5 .75 ,6 .0 1,治疗 1组药费与疗效比值明显低于治疗 2组及对照组。结论 :艾司奥美拉唑三联疗法是一种安全、高效的根除Hp方案。 3d疗法更为短程、经济。

AIM: To observe the clinic effect on the eradication of Helicobacter pylori(Hp) with esomeprazole , clarithromycin; amoxicillin triple therapy to seek the short-term and effective treating project. METHODS: One hundred and one Hp positive patients were randomly divided into 3 groups. Treatment group 1(n=31) was treated with esomeprazole 20 mg, bid, amoxicillin 1.0 g, bid and clarithromycin 0.5 g, bid, po×3 d. Treatment group 2 (n=35) was treated with the same medication and dosage as treatment group 1×7 d. Control group 3 (n=35) was treated with omeprazole 20 mg, bid, amoxicillin 1.0 g, bid, clarithromycin 0.5 g, bid, po×7 d. At 1 mo after treatment, the treated patients were evaluated by 13C-UBT. RESULTS: The Hp eradication rates of three groups(1,2,3) were 81 %, 86 %, 83 %(P>0.05).C/E were 2.52, 5.75, 6.01. The C/E of treatment group 1 was significantly lower than that of treatment group 2 and control group. CONCLUSIONS: Esomeprozle, clarithromycin and amoxicillin triple therapy is a safe and high-effective project on the eradication of Hp. There days therapy is more short and economic.