苯那普利对心衰大鼠模型的作用及其机制的探讨

Effect of Benazepril on cardiac failure model and its mechanism

目的 :探讨大鼠血浆血管紧张素II(AngⅡ )、醛固酮 (ALDO)在心力衰竭模型中的作用及其意义。方法 :采用缩窄大鼠腹主动脉造成压力负荷性心肌肥厚所致心力衰竭的大鼠模型。将正常喂养的 8周龄SD大鼠 ,随机分为 :心衰组 (n =34)、心衰治疗组 (n =34)及正常对照组 (n =16 )。采用放射免疫分析法 ,对 3组大鼠血浆AngⅡ、ALDO进行测定。结果 :心衰组大鼠血浆中AngⅡ、ALDO显著升高 ,与正常对照组比较 (P <0 .0 1) ,AngⅡ、ALDO与心力衰竭有一定相关性 (F >F0 .0 1) ,心衰治疗组在使用苯那普利后上述指标显著下降 (P <0 .0 1)。结论 :AngⅡ、ALDO在心力衰竭发病机制中起重要作用 ,苯那普利对心衰治疗及预后有积极的影响。

AIM: To study the effect of Benazepril on plasma angi ot ensin Ⅱ(AngⅡ) and aldosterone(ALDO) levels in the rat heart failure model. METHODS: The cardiac failure animal model in rats were made by coarc tating abdomial aorta to get pressure load. The rats aged 8 months were divid ed into three groups: the heart failure group(n=34), the treatment grou p(n=34)and the control group(n=16). Plasma angiotensin Ⅱ and aldost erone were measured by radioimmunoassay(RIA). RESULTS: The angiot ensin Ⅱ and aldosterone levels in the heart failure group were markedly higher than those in the others proups(P<0.01). It was shown that angiotensin Ⅱ a nd aldosterone levels in the rats were correlated with cardiac failure in this research. The angiotensin Ⅱ and aldosterone levels of the treatment group decr eased was obvious after benazepril therapy (P<0.01). CONCLUSION: Angiotensin Ⅱ and aldosterone played an important role in the pathogenes is of heart failure. Benazepril(ACEI) had a positive effect on the treatment and prognosis of cardiac insufficiency.