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肾上腺髓质素的表达与肿瘤的关系 被引量：2

Relationship between adrenomedullin expression and tumor
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摘要 肾上腺髓质素是一种具有广泛生理作用的生物活性肽,研究发现其在许多肿瘤中广泛分布,并主要通过以下几个方面在肿瘤的发生、发展中起重要作用:①刺激有丝分裂;②抑制免疫反应;③抑制凋亡;④刺激新血管的形成。 Adrenomedullin is a regulatory peptide involved in several physiological processes.Recently, adrenomedullin has been proved that it is widely expressed in tumor and may have a significiant role in tumor progression and differentiation by stimulating mitogenic activities, inhibiting immune response, inhibiting apoptosis and enhancing angiogenesis.
作者 于华
机构地区 青岛大学医学院附属医院
出处 《国外医学（放射医学核医学分册）》 2004年第5期213-216,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 肾上腺髓质素 肿瘤 缺氧诱导因子-1 补体因子H adrenomedullin tumor hypoxia-inducible factor-1 complement factor H
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

  • 1Ehlenz K, Koch B, Preuss P, et al. High levels of circulating adrenomedullin in severe illness: correlation with C-reactive protein and evidence against the adrenal medulla as site of origin[J]. Exp Clin Endocrinol Diabetes, 1997, 105(3): 156.
  • 2Friese MA, Hellwage J, Jokirahta TS, et al. Different regulation of factor H and FHL-1/reconnection by infmmatory mediators and expression of the two protein in rheumatoid arthritis (RA) [J]. Clin Exp Immunol, 2000, 121: 406-415.
  • 3Andreis PG, Markowska A, Champion HC, et al. Adrenomedullin enhancescell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: recepeor subtype involved and signaling mechanism[J]. Endocrinology, 2000, 141(6): 2098-2104.
  • 4Garayoa M , Martinez A, Lee S, et al. Hypoxia-nducible factor-1 (HIF-1) up-regulates Adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis[J]. Mol Endocrinol, 2000, 14(6): 848-862.
  • 5Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma [J]. Bichem Biophys Res Commun, 1993, 192(2): 553-560.
  • 6Martinez A, Miller MJ, Unsworth EJ, et al. Expression of adrenomedullin in normal human and in pulmonary tumors[J]. Endocrinology, 1995,136 (9): 4099-4105.
  • 7Udono T, Takahashi K, Nakayama M, et al. Adrenomedullin in cultured human retinal pigment epithelial cells [J]. Invest Ophthalmol Vis Sci, 2000, 41(7): 1962-1970.
  • 8Kapas S, Brown DW, Farthing PM, et al. Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP [J].FEBS Lett, 1997, 418(3): 287-290.
  • 9Hata K, Takebayashi Y, Akiba S, et al. Expression of the adrenomedullin gene in epithelial ovarian cancer[J]. Mol Hum Reprod, 2000, 6(10): 867-872.
  • 10Pio R, Martinez A, Unsworth EJ, et al. Complememt factor H is a serum binding protein for adrenomedullin. The resulting complex modulates the bioactivities of both partners[J]. Biol Chem, 2000, 276: 12292-12300.

同被引文献27

  • 1赵杨,郭科军,张颐,温放.细胞外信号调节激酶在卵巢癌中的表达及临床意义[J].中国肿瘤临床,2006,33(17):978-981. 被引量：5
  • 2李明群,刘少扬,江大琼.ADM在上皮性卵巢癌组织中的表达及其临床意义[J].实用癌症杂志,2006,21(4):373-375. 被引量：6
  • 3Zhong H,De Marzo A M,Laughner E,et al.Overexpression of hypoxia-induced factor in common human cancers and their metastases[J].Cancer Res,1999,59:5830-5835.
  • 4Ehlenz K,Koch B,Preuss P,et al.High levels of circulating adrenomedullin in severe illness:correlation with C-reactive protein and evidence against the adrenal medullas site of origin[J].Exp Clin Endocrinol Diabetes,1997,105:156-162.
  • 5王贤才.西氏内科学[M].第1版:世界图书出版公司,2003:163-166.
  • 6Allaker R P,Zihni C,Kapas S.An investigation into the antimicrobial effects of adrenomedullin on members of the skin,oral respiratory tract and gut microflora[J].FEMS Immunol Med Microbiol,1999,23:289-293.
  • 7Atanjan M, Saravanan SM, Elson DL. Advanced ovarian carcinoma as a chronic disease:a case report and reriew[J]. SO J Med, 2003, 56(12): 515-521.
  • 8Hata K, Takehayashi Y, Akiha S, et al. Expression of the adrenomedullin gene in epithelial ovarian cancer[J]. Mol Hum Reprod, 2000, 6(10): 867-872.
  • 9Giaealone PL, Vuaroqueaux V, Daures JP, et al. Expression of adrenomedullin in human ovaries, ovarian cysts and caneers. Correlation with estrogens receptor status[J]. Eur J Ohstet Gyneeol Reprod Biol, 2003, llO(2): 224-229.
  • 10Miller MJ, Martinez A, Unsworth EJ, et al. Adrenomedullin expression in human tumor cell lines: its potential role as an autocrine growth factor[J]. J Biol Chem, 1996,271(38): 23345-2335l.

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国外医学（放射医学核医学分册）
2004年 第5期

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