溶析结晶研究进展

Progress in Dilution Crystallization

溶析结晶是一种常见的分离提纯方法,广泛应用于化工、医药、食品等行业。近年来人们拓展了一些新的研究方向,比如显著影响结晶产品性质的溶析剂加入点的混合技术,与超临界流体技术耦合的溶析结晶微粒制造技术。本文从应用开发、动力学、聚集与混合、晶形与多晶型、超临界流体溶析结晶五个方面回顾了溶析结晶的研究进展。

Dilution crystallization is a usual method for separation and purification.It is widely used in chemical industry,pharmaceutical industry,food industry and so on.Some new research fields were extended in recent years,for instance,study on mixing technique of diluent entrance,where mixing situation markedly affect crystal characteristics and study on finely crystal preparation by dilution crystallization coupled with supercritical fluid technique.In this paper,the progress in five aspects including application and development,kinetics,mixing and agglomeration,crystal shape and polymorph and supercritical fluid dilution crystallization were reviewed for dilution crystallization.