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血管紧张素Ⅱ、巨噬细胞与急性冠状动脉综合征 被引量：1

Angiotensin Ⅱ Macrophages and Acute Coronary Syndrome
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摘要 斑块破裂并继发血栓形成是急性冠状动脉综合征 (ACS)的主要病理基础。单核细胞移行并聚集于斑块部位 ,成为巨噬细胞 ,表达组织肾素 血管紧张素系统 (RAS)多种成分 ;所释放的血管紧张素Ⅱ (AngⅡ )又从脂质代谢、炎症和细胞促凝活性等多角度调节巨噬细胞功能。两者相互作用 ,共同参与ACS病理过程。血管紧张素转化酶抑制剂 (ACEI)、血管紧张素Ⅱ受体拮抗剂(ARB)减少心血管事件的发生 ,其稳定斑块的作用与以上机制有关。
作者 吴超能 蒲晓群
机构地区 中南大学湘雅医院心内科
出处 《心血管病学进展》 CAS 2004年第6期447-449,共3页 Advances in Cardiovascular Diseases
关键词 急性冠状动脉综合征 巨噬细胞 ACS 血管紧张素Ⅱ受体 斑块 病理基础 血管紧张素Ⅱ(AngⅡ) 促凝活性 病理过程 拮抗
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献20

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二级参考文献19

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共引文献43

同被引文献11

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心血管病学进展
2004年 第6期

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