摘要
目的比较磷酸铝凝胶国产仿制品(制剂A)与原研发产品(制剂B)的理化作用差异。方法分析不同国家法定标准对磷酸铝制剂的要求,即从性状、动态抗酸力、不同浓度食物对抗酸力的影响、对H+的绝缘能力、粘度、沉降速率等几方面对两种产品进行比较。结果制剂A挂壁效果、抗酸力、对H+的绝缘能力、动力粘度等均不如制剂B;低浓度的食物对两者的抗酸力无显著影响;两种制剂均存在批间差异。结论磷酸铝凝胶原研发产品在理化作用方面优于国产仿制品。
OBJECTIVE:To compare the physical chemistry properties of copying(A) and original(B) aluminium phosphate gel METHODS:We examined the character,antacid activity,isolating capacity against H+ ions and viscosity in different pH values of two products RESULTS:Product A was not better than product B in the Character,antacid activity,isolating capacity against H+ ions and viscosity;The antacid activity of two preparations not influenced obviously by the food with low concentration;Two preparations all had difference physical chemistry properties in batches CONCLUSION:Product B was better than A in comparison of the physical chemistry properties
出处
《中国药房》
CAS
CSCD
2004年第11期663-666,共4页
China Pharmacy
关键词
磷酸铝凝胶
理化作用
比较
aluminium phosphate gel
physical chemistry properties
comparison
