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诱导心脏发生的早期信号通路 被引量：3

Early Signaling Pathways During Cardiogenesis
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摘要 心脏是胚胎发生过程中最早形成的器官 .心脏前体的特化是组织间及细胞与细胞之间相互作用的结果 ,这一过程包含了诱导信号作用的时间和空间完整程序 .以脊椎动物和无脊椎动物作为模式动物 ,总结了在早期心脏发生中发挥重要作用的诱导信号通路 :BMP Dpp ,Wnt Wingless ,FGF及Notch信号通路 ,并阐述了信号通路之间的通讯 (crosstalk)以及信号通路与心脏发生相关的关键转录调节因子之间的协同诱导作用 . The heart is the first organ to form during embryogenesis. The specification of heart precursors is a result of multiple tissues and cell-cell interactions that involve temporally and spatially integrated programs of inductive signaling events. The functions of the major signaling pathways BMP/Dpp,Wnt/Wingless,FGF and Notch are summarized during early cardiogenesis in both vertebrate and invertebrate models. The crosstalk among inductive signaling pathways and the relationships between signaling and cardiogenic transcriptional regulators that cooperate to control cardiac induction is also discussed in this review.
作者 王春梅 姜涛 周春燕
机构地区 北京大学基础医学院生物化学与分子生物学系
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2004年第5期572-577,共6页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家高技术研究发展计划 ( 863计划 )基金 (No .2 0 0 1AA2 160 3 13 ) 北京市科技计划重大项目基金 (No .H0 2 0 2 2 0 0 10 490 ) 教育部 2 11工程项目 北京大学 985基金资助项目~~
关键词 心脏发生 信号通路 BMP/Dpp Wnt/Wingless FGF NOTCH cardiogenesis, signaling pathway, BMP/Dpp, Wnt/Wingless, FGF, Notch
分类号 Q593 [生物学—生物化学] Q132.7 [生物学—普通生物学]
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参考文献23

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同被引文献26

  • 1林先和,李隆贵.转录因子与心脏发育[J].心脏杂志,2004,16(5):480-481. 被引量：2
  • 2向建军,许榕仙.叶酸及同型半胱氨酸与心血管疾病研究进展[J].海峡预防医学杂志,2005,11(5):32-34. 被引量：5
  • 3李静,刘石,彭宇竹,陈吉庆,郭锡熔.叶酸缺乏对孕鼠子代心脏中NKx2.5基因表达的影响[J].实用儿科临床杂志,2006,21(1):20-22. 被引量：3
  • 4Jorge L,Sepulveda SV.Dinakariyer combinatorial expression of GATA4,Nkx2-5,and serum response factor directs early cardiac gene activity[J].J Biol Chem,2002,277 (28):25775-25782.
  • 5Lee KH,Evans S,Ruan TY,et al.SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer[J].Development,2004,131(19):4709-4723.
  • 6Smoak IW.Hypoglycemia and embryonic heart development[J].Front Biosci,2002,7(1):d307-18.
  • 7Soliman AT,Madkour A,Galil MA,et al.Growth parameters and endocrine function in relation to echocardiographic parameters in children with ventricular septal defect without heart failure[J].J Trop Pediatr,2001,47(3):146-12.
  • 8Zile MH.Function of vitamin A in vertebrate embryonic development[J].J Nutr,2001,131 (3):705-708.
  • 9Fishman MA.Birth Defects and Supplemental Vitamins[J].Curr Treat Options Neurol,2000,2(2):117-122.
  • 10Tang LS,Wlodarczyk B J,Santillano DR,et al.Developmental consequences of abnormal folate transport during murine heart morphogenesis[J].Birth Defects Res A Clin Mol Teratol,2004,70(7):449-58.

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中国生物化学与分子生物学报
2004年 第5期

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